New Discovery May Halt Osteoarthritis Progression.

Arthritis National Research Foundation Grant Recipients Discover Body’s Own Molecular Protection Against Arthritis.

An international team of scientists, led by ANRF grant recipients Dr. Hiroshi Ashara (2000-2001) and Dr. Shigeru Miyaki (2009-2011), from The Scripps Research Institute in California in conjunction with the National Research Institute for Child Health and Development in Japan, has discovered that a natural molecule in the body counters the progression of osteoarthritis. The findings are exciting and could one day lead to new therapies for individuals suffering with osteoarthritis. The research team focused on the molecule, microRNA 140. The molecule is part of a recently discovered category of genetic molecules called — “microRNAs” or “non-coding RNAs” which often play a vital role in gene expression.

Osteoarthritis currently affects an estimated 20 million Americans and is the most common joint disorder. As our population ages, this number is expected to increase by 50 percent over the next two decades. Current treatments for osteoarthritis focus on reducing pain and inflammation. This discovery is the first breakthrough in stopping and fighting the progression of osteoarthritis.

“This is the first report showing the critical role of a specific non-coding RNA in bone development,” said Hiroshi Asahara, M.D., Ph.D., associate professor of molecular and experimental medicine at The Scripps Research Institute. “Moreover, surprisingly, we observed that microRNA 140 acts against arthritis progression. This is among the first evidence that non-coding RNA plays a key role in age-dependent diseases.”

Osteoarthritis is a degenerative disease in which joint cartilage breaks down due to wear and tear on joints as we age or as a result of injury. Dr. Miyaki says, “This finding may lead to a new therapeutic strategy for osteoarthritis, as well as for conditions that share similar mechanisms, such as spinal disc degeneration.” This new breakthrough opens the door to find new methods to not only treat and stop osteoarthritis, but also reverse its effects all together. And, because the molecule occurs naturally in the body ill side effects would be minimal. New treatments and therapies may be able to correct our body’s natural tendency to break down as we age and allow for a better quality of life.

Source The Scripps Research Institute Press Release

Bipasha’s inspirational battle against arthritis!

Bipasha Basu suffers from and is getting treated for acute Osteoarthritis, a condition that is rare among younger people or even who are in their thirties. Osteoarthritis is a condition that makes your bones weak and brittle, leaving you incapable of doing any strenuous exercise.

The condition was traced way back in 2005 when Bipasha hurt herself while working out on the treadmill. Over the years, exercising started becoming more difficult and there came a day when Bipasha even found it difficult to run on the treadmill. Even though the doctors asked her not to undertake any strenuous exercises, the brave lady of Bollywood has proven all of them wrong. Bipasha has not only conquered her disease, she is one of the fittest actors around. Being a fitness freak,not a day goes by when she misses her exercise routine.

So, how did she manage to do the impossible?

The actress is taking Glucosamine Chondrotin supplements which prevent cartilage damage during exercises. If you have Osteoarthritis, then your cartilages might get frequently damaged during intensive workouts. The actress takes good care of her body and ensures that she has a diet that is wholesome and good for the body. If you are wondering about how did she know about her medical condition, she had no knowledge about health and fitness and frequently went on crash diets to maintain her weight. Suddenly, one day, Bipasha started feeling an excruciating pain in her knees. In the coming days, she could barely stand. Bipasha called Hrithik Roshan and Shah Rukh Khan who recommended some top doctors. The doctor treated Bipasha asked her to undergo an MRI (Magnetic Resonance Imaging) Scan and the reports made her go numb with shock. The reports said that she is suffering from an extreme condition and her knees had become like that of a 65-year-old person. The condition was extremely rare in youngsters who are in their 20s and 30s. From there on, Bipasha made up her mind that she will take care of her body well and promised to be one of the fittest actors in the industry and the rest is history. Well, Isn’t that a story of inspiration for all of us?

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